Crop improvement by breeding, biofortification and transgenics · GS-III
Indian farmers may grow world’s first gene edited rice variety this winter ↗
Consider the following pairs regarding gene-editing classifications and their regulatory treatment in India:
- SDN1 (Site Directed Nuclease 1) — Introduces exogenous (foreign) DNA and is therefore subject to biosafety regulation under Rules 7–11 of Rules 1989 under the Environment (Protection) Act, 1986
- SDN2 (Site Directed Nuclease 2) — Mutates a native gene in its native location without introducing foreign DNA; exempt from biosafety regulation under the Environment (Protection) Act, 1986
Which of the pairs given above is/are correctly matched?
Explanation
SDN1 (Site Directed Nuclease 1) does NOT introduce exogenous (foreign) DNA. Like SDN2, it mutates a native gene in its native location to create an alternative allele with an altered expression and function. The mutants produced by both SDN1 and SDN2 are free of externally introduced DNA and are indistinguishable from spontaneous or induced mutants. Precisely because of this, both SDN1 and SDN2 products are exempted from biosafety regulation under Rules 7–11 of the Environment Protection (Rules) 1989, under the Environment (Protection) Act, 1986. Pair 1 is therefore incorrectly described — it falsely attributes 'foreign DNA introduction' to SDN1, which is actually the distinguishing feature of the more tightly regulated SDN3 category. Pair 2 is correctly described for SDN2.